Fig. 1: A comprehensive network featuring genetic regulation and glucose, fatty acid, and glutamine metabolism in cancer.
From: Computational modeling of cancer cell metabolism along the catabolic-anabolic axes
The ovals represent genes. The red ovals highlight the two master regulators of metabolism—AMPK and HIF-1. The green ovals represent oncogenes and the downstream target genes of AMPK and HIF-1. The orange ovals represent enzyme genes. The yellow rectangles represent metabolites. The black arrows represent excitatory regulatory links, and the black bar-headed arrows represent inhibitory regulatory links. The purple solid lines represent the chemical reactions involved in the metabolic pathways. The purple dotted lines represent the transportation of metabolites.
