Fig. 10: DynCMEval simulation outcome for different parameters for the pathogen C. albicans and its comparison to conCMEval simulations. | npj Systems Biology and Applications

Fig. 10: DynCMEval simulation outcome for different parameters for the pathogen C. albicans and its comparison to conCMEval simulations.

From: Complex-mediated evasion: modeling defense against antimicrobial peptides with application to human-pathogenic fungus Candida albicans

Fig. 10

a Survival probabilities of C. albicans for different parameter sets. The color shows the survival probability of the pathogen for a particular parameter set. Higher values (dark blue) correspond to the immune-evasion regime, with high chances for the pathogen to survive, whereas lower values (yellow) correspond to a probability of survival for the pathogen cell close to \(0 \%\). Parameter values used in the simulations are presented in Supplementary Table 4. b Boxplot of the probability of survival of the parameter screening for the conCMEval simulations (blue), and for the different values of \({F}_{{LL}37}\) of the dynCMEval simulations. The black line on the boxes indicates the median value. The comparison between the two models was performed by a Kruskal-Wallis test. The significance shown by \(* * *\) indicates \({P}_{\mathrm{val}} < 0.001\), and \(\mathrm{ns}\) – \({P}_{val} > 0.05\).

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