Fig. 3: Continuous and pulsed schedules under linear induction of tolerance.
From: Optimal dosing of anti-cancer treatment under drug-induced plasticity
a Long-run average growth rate of the tumor under a range of possible pulsed schedules of the form (c, φ), where c is the drug dose applied and φ is the proportion of drug exposure. The red curves show for each exposure proportion φ the optimal dose c*(φ) to give. The red dots show the optimal pulsed schedules, which are continuous for Cases I, II and III, consistent with our results in Fig. 2. b Long-run average growth rate under the optimal dose c*(φ), shown as a function of the proportion φ of drug exposure. c Average dose applied during each treatment cycle under the optimal dose c*(φ), shown as a function of the proportion φ of drug exposure, normalized to the average dose under the optimal schedule.
