Fig. 5: Box and whisker plots of posterior parameter distributions for each treatment protocol.
From: Modeling tumor dynamics and predicting response to therapies in a murine pancreatic cancer model
Specifically, parameter distributions for proliferation rate (r) and death rate due to treatment (α) are displayed in (A) and (B), respectively. Bayesian distributions are displayed for control (blue) and each treatment, split into responders (green) and non-responders (red). Responders exhibit statistically lower proliferation rates and greater death rates due to treatments (p-adjusted < 0.001). In particular, T2—NGC + losartan and T3—NGC + calcipotriol induce the greatest death rate due to the regimes. T4—calcipotriol performed the worst, with both the highest tumor proliferation rate and lowest death rate due to treatment. Note that neither T4—calcipotriol nor T5—NGC + calcipotriol + anti-PD-L1 had any responders.
