Table 1 Parameter definitions and uniform priors for inference of treatment arm parameters

From: Modeling tumor dynamics and predicting response to therapies in a murine pancreatic cancer model

Parameter

Meaning

Prior

N0

initial tumor volume

\({\mathcal{U}}(0,600)\) mm3

r

tumor proliferation rate

\({\mathcal{U}}(0.03,0.3)\) d−1

α

tumor death rate by treatment

\({\mathcal{U}}(0,0.3)\) d−1

β

treatment effect decay

\({\mathcal{U}}(0,2)\)

  1. \({\mathcal{U}}(a,b)\) denotes a uniform distribution with bounds a and b for the prior values of the parameter. These bounds are determined using prior predictive checks with the control data. For the control, we assume that the proliferation rate r is uniformly distributed over (0, 0.5) d−1, the carrying capacity K over (1, 3000) mm3, and the initial volume N0 over (0, 600) mm3. We also note that the bounds for the proliferation rate for the treatment arms are based on the posterior distribution of the control for that parameter.
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