Fig. 2: The epigenetic attractor landscape shows an attractor associated with each BC subtype.
From: NF-κB epigenetic attractor landscape drives breast cancer heterogeneity
A Model calibration to the estimated RNA molecule numbers of NF-κB subunits (p50, p65) and transcription factors (SLUG, SIP1, and TWIST). Orange bars represent the same data as shown in Fig. 1C, while purple bars depict the calibration of the GRN model. B Fine-tuning of model parameters to replicate the temporal dynamics of expression level recovery in HER2+ (upper panel) and TNBC (lower panel) cell subtypes after treatment with the NF-κB inhibitor DHMEQ. C The three stationary states in the p50-p65 phase space, with the purple line showing the trajectory of a single-cell simulation undergoing the HER2+ to TNBC transition. D–F Three different perspectives of the model attractor basins.
