Table 1 Effects of mutations on the size of attractor basins
From: NF-κB epigenetic attractor landscape drives breast cancer heterogeneity
Wild-type | p65 degradation 2.5% lower | p65 degradation 5% higher | |||||||
|---|---|---|---|---|---|---|---|---|---|
Specie (molecule number) | HER2 | Unstable | TN | HER2 | Unstable | TN | HER2 | Unstable | TN |
p50 | 32491.3 | 76472 | 150491 | 33968.8 | 68630.7 | 156382 | 30449.1 | 96943 | 133008 |
p65 | 115566 | 260132 | 535271 | 123303 | 239395 | 573457 | 103958 | 316153 | 444084 |
NFkB | 5893.33 | 31221.9 | 126429 | 6573.79 | 25786.8 | 140751 | 4968.14 | 48103.6 | 92705,9 |
RNAp50 | 104.38 | 245.66 | 483.44 | 109.12 | 220.47 | 502.36 | 97.82 | 311.42 | 427.28 |
RNAp65 | 134.99 | 303.86 | 625.25 | 140.43 | 272.65 | 653.11 | 127.50 | 387.76 | 544.67 |
p50 variation (%) | 4.55 | −10.25 | 3.91 | −6.29 | 26.77 | −11.62 | |||
p65 variation (%) | 6.69 | −7.97 | 7.13 | −10.04 | 21.54 | −17.04 | |||
NFkB variation (%) | 11.55 | −17.41 | 11.33 | −15.70 | 54.07 | −26.67 | |||
RNAp50 variation (%) | 4.55 | −10.25 | 3.91 | −6.29 | 26.77 | −11.62 | |||
RNAp65 variation (%) | 4.03 | −10.27 | 4.46 | −5.55 | 27.61 | −12.89 | |||
HER2-to-instable distance | 151108.01 | 121156.10 | 222369.42 | ||||||
TN-to-instable distance | 284921.54 | 345395.01 | 132917.36 | ||||||
HER2-to-unstable distance variation (%) | −19.82 | 47.16 | |||||||
TN-to-unstable distance variation (%) | 21.22 | −53.35 | |||||||
