Table 2 Some O-SNE and P-SNE biomarkers in ESCA, HNSC, and UCEC
Tumor | Type | Gene | Family | Relationship with tumor progression |
|---|---|---|---|---|
ESCA | P-SNE | TP53INP1 | Cytosol | TP53INP1 plays a key role in the progression of undifferentiated carcinoma44. |
O-SNE | HPR | Extracellular | HPR treatment was shown to modulate cell morphology and suppress growth in esophageal squamous carcinoma models45. | |
HNSC | P-SNE | DPH3 | Cytosol | DPH3 promoter mutations were found to functionally correlate with solar lentigines development at tumor sites46. |
O-SNE | SMARCAL1 | Nucleus | SMARCAL1 expression serves as a diagnostic and prognostic biomarker in multiple cancer types, particularly in glioma47. | |
UCEC | P-SNE | NOTCH1 | Cytosol | NOTCH1 plays a critical role in tumorigenesis across multiple cancer types through its involvement in proliferation and survival pathways48. |
O-SNE | API5 | Nucleus | API5 is highly expressed in cancer cells and promotes the maintenance of stemness characteristics49. |
