Fig. 5: Influence of bioprocessing search filters on journal and subject category distribution in CHO and HEK293 studies.

A Relative journal distribution for studies retrieved with and without bioprocess terms across CHO (blue), HEK293 (purple), and combined (green) cell line datasets. Each panel shows normalised frequencies of the top journals, comparing studies that include bioprocess search terms (right bars) versus those that do not (left bars). Journal frequencies were normalised by the total number of publications in each dataset to enable fair comparison across groups of different sizes. The CHO dataset shows a broader journal spread, while the HEK293 and combined cell line panels reveal narrower journal representation. This highlights how the inclusion of bioprocess filters influences not only the number of publications retrieved but also the types of journals where those studies appear. Journal names have been replaced with numerical identifiers. B Top WoS categories for CHO (blue) and HEK293 (purple) studies, comparing bioprocess-specific and broader multi-omics searches. CHO studies appear in both applied and diverse academic categories, with bioprocess-tagged records showing stronger alignment with Biochemical Research Methods and Biotechnology. HEK293 studies are more numerous overall but lack bioprocess-specific entries, remaining collected under general biomedical categories. Category distribution reflects both dataset size and research focus orientation.