Fig. 6: Effect of recovery from toxicity, γ, on the nature of treatment failure.
From: Delaying cancer progression by integrating toxicity constraints in a model of adaptive therapy
As \(\gamma\) increases, the reason for treatment failure switches from sensitive to resistant cells. A Daily with toxicity and B adaptive with toxicity protocols when drug effectiveness, \(\delta\), is small (\(\delta =2/3\)). C Daily with toxicity and D adaptive with toxicity protocols when \(\delta\) is large (\(\delta =4/3\)). The remaining parameters are fixed at their baseline value in Table 1.
