Table 1 Baseline parameter values used in Eqs. (1)–(4)
From: Delaying cancer progression by integrating toxicity constraints in a model of adaptive therapy
Parameter | Description | Value | Dimensions |
|---|---|---|---|
\({{\boldsymbol{\alpha }}}_{{\boldsymbol{S}}}\) | Growth rate of sensitive cancer cells | 1 | per day |
\({{\boldsymbol{\alpha }}}_{{\boldsymbol{R}}}\) | Growth rate of resistant cancer cells | \(\epsilon {\alpha }_{S}\) | per day |
\({\boldsymbol{\epsilon }}\) | Dimensionless constant between 0 and 1 | 0.4 | dimensionless |
\({\boldsymbol{K}}\) | Shared carrying capacity | 100 | dimensionless |
\({\boldsymbol{\delta }}\) | Rate of drug-induced cancer cell death | 1 | per day |
\({\boldsymbol{\beta }}\) | Competition parameter between sensitive and resistant cancer | 2.4 | dimensionless |
\({\boldsymbol{\lambda }}\) | Drug clearance rate | 0.693 | per day |
\({\boldsymbol{\mu }}\) | Rate of toxicity accumulation | 1 | per day |
\({\boldsymbol{\gamma }}\) | Toxicity recovery rate | 0.4 | per day |
Rxoff | Efficacy threshold triggers therapy pause if total tumor size falls below this value | 40% of initial tumor size | dimensionless |
Rxon | Efficacy threshold triggers therapy restart if total tumor size surpasses this value | Initial tumor size | dimensionless |
Toxoff | Toxicity threshold triggers therapy pause if toxicity surpasses this value | 2 | dimensionless |
Toxon | Toxicity threshold triggers therapy restart if toxicity falls below this value | 1 | dimensionless |
Treatment Failure | Tumor size defining treatment failure and disease progression | 75 | dimensionless |
