Fig. 10: Lineage tracing in four simulation runs (Model 2). | npj Systems Biology and Applications

Fig. 10: Lineage tracing in four simulation runs (Model 2).

From: Modeling epithelial deformation and cell rearrangement in response to external forces during Zebrafish epiboly

Fig. 10: Lineage tracing in four simulation runs (Model 2).The alternative text for this image may have been generated using AI.

In each run, some cells were labeled red at initialization (30% epiboly, in lateral view, left); all cells retain their color through the entire simulation and are shown in their final positions (99% epiboly, right; with the vegetal pole marked by a white dot). Cell division was disabled so that any change in the geometry of the labeled region can be attributed simply to cell rearrangement, without any confounding effects of cell division. a EVL leading edge cells are labeled. Many of these cells move away from the edge during epiboly, resulting in several tiers of labeled cells. By the end of epiboly, shown in vegetal view, a large area around the vegetal pole is composed mostly of cells originally at the leading edge. Intermingling of labeled and unlabeled cells is evident. (See Supplementary Movie 10). b Tier 1 of internal EVL cells are labeled. (See Supplementary Movie 11). c A patch of EVL cells on one side of the embryo is labeled, adjacent to the leading edge. In this example, the patch remains in contact with the leading edge, as is typical. Final view is from an oblique angle. (See Supplementary Movie 13). d A patch of EVL cells is labeled as in (c) and viewed from the same angles. In this case, the patch migrates away from the edge entirely. (See Supplementary Movie 14).

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