Table 1 Current malaria vaccines under preclinical development or in clinical trials

From: Advances in malaria vaccine development: report from the 2017 malaria vaccine symposium

Parasite stage

Vaccine classification

Current status

Pre-erythrocytic stage

PfSPZ vaccine

Whole organism (radiation attenuation)

Phase II

GAP vaccines

Whole organism (genetic attenuation)

Phase I

RTS,S

Subunit

Phase IV

CVac

Whole organism (chemical attenuation)

Phase I

Blood stage

Chemically attenuated parasites

Whole organism

Preclinical

 AMA1-RON2

Subunit

Preclinical

 PfRH5

Subunit

Phase I

Mosquito stage (TBVs)

Pfs25

Subunit

Phase I

Pfs230

Subunit

Phase I

Pfs47

Subunit

Preclinical

  1. Pre-erythrocytic, blood-stage and transmission-blocking vaccines are being evaluated in clinical trials (denoted as phases I to IV) or are being tested in rodent or non-human primate models (preclinical status).
Back to article page