Fig. 2 | npj Vaccines

Fig. 2

From: LepVax, a defined subunit vaccine that provides effective pre-exposure and post-exposure prophylaxis of M. leprae infection

Fig. 2

Experimental set-up to examine post-exposure immunoprophylaxis in M. leprae-infected armadillos. Armadillos underwent intravenous inoculation with M. leprae, then 1 month later were: left untreated (unimmunized); immunized with BCG (BCG) one time; immunized with ID93 + GLA-SE, for a total of three times at monthly intervals or; immunized with LepVax (LEP-F1 + GLA-SE), for a total of three times at monthly intervals. The animals were monitored for compound muscle action potential (CMAP) and motor nerve conduction velocity (NCV) at monthly intervals, underwent three mm skin punches 16 months, and had their posterior tibial nerves (TN) biopsied at 28 months, after M. leprae inoculation. The photograph is the authors own

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