Table 1 Anti-SU IgG fraction neutralizes in vitro FIV infection whereas whole serum enhances infection

From: FIV vaccine with receptor epitopes results in neutralizing antibodies but does not confer resistance to challenge

Treatment

Factors removed from Serum

Immune factors retained in serum

Effect on FIV replication in vitro

Whole serum Sham group

NA

Complement and heat labile factors

NA

Whole serum CD134 group

NA

Complement and heat labile factors

anti-CD134 IgG

anti-293S IgG

Enhancement

Whole serum

CD134+SU group

NA

Complement and heat labile factors

anti-SU IgG

anti-CD134 IgG

anti-293S IgG

Enhancement

Heat-treated serum

Sham group

Complement (inactivated)

Heat labile factors (inactivated)

NA

NA

Heat-treated serum

CD134 group

Complement (inactivated)

Heat labile factors (inactivated)

Anti-CD134 IgG

anti-293S IgG

NA

Heat-treated serum

CD134+SU group

Complement (inactivated)

Heat labile factors (inactivated)

Anti-SU IgG

anti-CD134 IgG

anti-293S IgG

Inhibition

Serum enriched for anti-SU

Complement (inactivated)

Heat labile factors (inactivated)

anti-CD134 IgG

anti-293S IgG

Anti-SU IgG

Inhibition

Serum enriched for anti-CD134

Complement (inactivated)

Heat labile factors (inactivated)

anti-SU IgG

anti-293S IgG

Anti-CD134 IgG

NA

Serum enriched for anti-293S

Complement (inactivated)

Heat labile factors (inactivated)

anti-SU IgG

anti-CD134 IgG

Anti-293S IgG

NA

  1. Whole serum from CD134 and CD134+SU vaccinated cats significantly enhanced FIV replication in vitro. Heat inactivation of whole serum from CD134+SU vaccinated cats resulted in in vitro inhibition, suggesting enhancing factors in whole serum are heat-labile. Anti-SU antibodies generated in CD134+SU vaccinated cats exhibit significant individual or combined inhibitory effects on FIV replication following heat-treatment to remove heat-labile proteins in serum, while serum enriched for anti-CD134 and anti-293S fractions neither inhibited or enhanced in vitro infection