Fig. 2 | npj Vaccines

Fig. 2

From: Single dose of DPX-rPA, an enhanced-delivery anthrax vaccine formulation, protects against a lethal Bacillus anthracis spore inhalation challenge

Fig. 2

Vaccination with DPX-rPA generates rapid, functional antibody response in rabbits. a, b Groups of eight New Zealand White rabbits were vaccinated once (Week 0) with 10 µg DPX-rPA (black circles) or three times (Weeks 0, 4, and 16) with 10 µg alum-rPA control vaccine (black x). Results are shown as mean ± SEM. a Endpoint anti-rPA immunoglobulin G (IgG) titers, presented as Log10 values, between Weeks 4 and 36 post immunization determined by enzyme-linked immunosorbent assay (ELISA). Immunizations are temporally indicated with arrows along the x-axis. b Anthrax toxin-neutralizing activity of IgG antibodies, presented as Log10 toxin-neutralizing assay (TNA) (ED50 (50% effective dose)), at Weeks 4 and 20 post immunization with alum-rPA or DPX-rPA vaccines determined by TNA. Individual responses shown with mean value indicated with a line and ±SEM. Significance was determined by two-way analysis of variance (ANOVA) with Bonferroni post test; *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, NS: not significant

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