Fig. 3: HA-specific CD4 T-cell responses post vaccination for individuals. | npj Vaccines

Fig. 3: HA-specific CD4 T-cell responses post vaccination for individuals.

From: Recombinant HA-based vaccine outperforms split and subunit vaccines in elicitation of influenza-specific CD4 T cells and CD4 T cell-dependent antibody responses in humans

Fig. 3

CD4-enriched populations of cells from the subjects vaccinated with Fluzone (top), Flucelvax (middle) or Flublok (bottom) were stimulated with pools of peptides from the HA indicated. H1-specific responses are shown in black bars, H3 in white and HA-B in grey. IFN-γ cytokine producing cells were quantified using EliSpot assays. The data are represented as a stacked bar for each vaccinated individual and the year of the study is indicated at the bottom of the graphs. A dotted line indicates the 100-spot cutoff used to estimate a positive CD4 T-cell response. The boxed number at the top of each panel is the percent response-based frequency using this cutoff for each vaccine.

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