Fig. 4: The more robust CD4 T-cell response to Flublok post vaccination is not determined by HA dose within the vaccine. | npj Vaccines

Fig. 4: The more robust CD4 T-cell response to Flublok post vaccination is not determined by HA dose within the vaccine.

From: Recombinant HA-based vaccine outperforms split and subunit vaccines in elicitation of influenza-specific CD4 T cells and CD4 T cell-dependent antibody responses in humans

Fig. 4

A group of 21 healthy subjects, aged 18–49 years old were vaccinated with high dose trivalent Fluzone (blue) and compared to those subjects in years 1 and 2 that received trivalent Flublok (red). CD4-enriched populations were stimulated with pools of peptides from H1, H3 and HA-B and evaluated for IFN-γ production using cytokine EliSpot assays. The data are represented as the change in the response between day 0 and day 14 (D14–D0), with the median response indicated by a black line. The specific HA reactivity is indicated above the panels, with H1 on the left, H3 in the middle and HA-B on the right. The p values shown were calculated by the Wilcoxon rank sum test.

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