Fig. 6: Antibody responses to vaccination as measured by HAI assay. | npj Vaccines

Fig. 6: Antibody responses to vaccination as measured by HAI assay.

From: Recombinant HA-based vaccine outperforms split and subunit vaccines in elicitation of influenza-specific CD4 T cells and CD4 T cell-dependent antibody responses in humans

Fig. 6

The neutralizing serum antibody response at day 0 before vaccination and day 28 post vaccination was measured by HAI assays from subjects vaccinated with Fluzone (blue), Flucelvax (gold) or Flublok (red). Shown in a is the fold-change between day 0 and day 28 (D28/D0) for each of the HA strains contained in the vaccine, H1 (top left), H3 (top right), HA-B Brisbane (Victoria lineage, bottom left) and HA-B Phuket (Yamagata lineage, bottom right). The data from individuals are represented by the scatter and the geometric mean is indicated by a black line. A dotted line indicating the fourfold response, typically used to indicate a positive antibody response, is shown. The p values were calculated by the Wilcoxon rank sum test. The table in b indicates the percent responders for each vaccine, indicated on the rows to the left, and each HA, indicated on the columns above, based on a fourfold or greater HAI response.

Back to article page