Table 1 Immunological readouts (A) and desirability function parameters (B–D).

From: Preclinical optimization of an enterotoxigenic Escherichia coli adjuvanted subunit vaccine using response surface design of experiments

Y

A

B

C

D

 

Immune response

Lower bounds (log10)

Upper bounds (log10)

Weighting

Y1

Day 21 serum HAI

2.17

3.31

4

Y2

Day 35 serum HAI

3.60

4.52

3

Y3

Day 35 IW HAI

2.17

3.01

5

Y4

Day 21 serum LT neutralization

1.33

3.86

4

Y5

Day 35 serum LT neutralization

2.98

5.32

3

Y6

Day 35 IW dmLT IgG

3.10

5.19

1

Y7

Day 35 IW CfaEB IgG

3.52

5.32

1

Y8

Bone marrow dmLT ASCs

1.09

2.42

2

Y9

Bone marrow CfaEB ASCs

1.97

3.00

2

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