Table 1 Serum antibody titers of C. muridarum-exosomes vaccinated mice the day before the i.n. challenge.

From: Induction of protection in mice against a respiratory challenge by a vaccine formulated with exosomes isolated from Chlamydia muridarum infected cells

Vaccine

GMT (range) to C. muridarum EB

GMT (range) to C. muridarum rMOMP

Serum neutralizing GMT (range)

IgG

IgG1

IgG2a

IgG

IgG1

IgG2a

C. muridarum-exosomes

25,600a (25,600–25,600)

3200a (1600–6400)

9051a (6400–12,800)

9051a (6400–12,800)

358a (160–800)

9051a (6400–12,800)

8611a (5120–10,240)

Control-exosomes

<200

<200

<200

<100

<100

<100

<20

PBS

<200

<200

<200

<100

<100

<100

<20

  1. aSignificant (P < 0.05) by the Kruskal–Wallis test compared to the control-exosomes or PBS immunized groups
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