Fig. 7: Magnitude and specificity of antibody responses in IDLV + protein vaccinated animals correlate with time to virus acquisition.

a ELISA binding of plasma antibodies to CH505 T/F Env at the peak and six months post-each immunization with IDLV-CH505 + protein (group B2 animals). Each dot represents one animal. b Number of challenges to virus acquisition for each animal in groups B1 and B2. c Serum neutralization activity against the clade C tier1 virus CH505.w4.3 at the indicated time points. d Comparison of linear epitope specificities between animals in B1 and B2 vaccine groups (red dots), animals with viral loads above or below 250 copies/mL (blue dots) and animals that required either <6 or >6 challenges to become infected (yellow dots). Significant differences fall above the horizontal line and are listed in the text box below the figure for each comparison. e The peptide range and the aa position for each epitope are indicated.