Fig. 4: Peripheral follicular helper T (pTFH) cell analysis. | npj Vaccines

Fig. 4: Peripheral follicular helper T (pTFH) cell analysis.

From: Reduced immune responses to hepatitis B primary vaccination in obese individuals with nonalcoholic fatty liver disease (NAFLD)

Fig. 4

A Serum CXCL13 B serum IL-21 levels in pg/mL at baseline and post vaccination in 31 NAFLD patients. C Spearman’s rank correlation between baseline CXCL13 and anti-HBs levels in NAFLD, r = −0.5, p = 0.009. D Frequency of pTFH in PBMC among NAFLD patients. E HBsAg specific CXCL13 production by pTFH cocultured with B cells. Sorting experiments were carried out in N = 19/21 responders and N = 9 non/low responders. Data are presented as mean ± standard deviation. R normal and high responders, anti-HBs > 100 IU/L, NR/LR nonresponders and low responders, anti-HBs < 100 IU/L, unstim unstimulated, stim stimulated.

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