Table 1 Summary of behavior analysis.
From: Nasal vaccine delivery attenuates brain pathology and cognitive impairment in tauopathy model mice
Tests | FTLD-tau/control-v vs. control/control-v | FTLD-tau/tau-v vs. FTLD-tau/control-v | Related behavioral abnormalities | Assessed regions | Figures |
|---|---|---|---|---|---|
Elevated plus maze test | Less hazard perceptive (p < 0.0001) | Improved (p = 0.0379) | Anxiety, hazard perception | Cognitive system (hippocampus, cingulate cortex) | Fig. 4a |
Barnes maze test | Memory loss (p = 0.0064) | Improved (p = 0.0385) | Spatial working memory, reference memory | Cognitive system (hippocampus) | Fig. 4b–d |
Contextual fear conditioning test | Less hazard perceptive (p = 0.0257) | Improved (p = 0.0042) | Contextual memory, hazard perception | Cognitive system (hippocampus, amygdala) | Fig. 4e–g |
Body weight | Decreased (p = 0.0233) | No change | – | – | Suppl. Fig. 4a |
Body temperature | Tendency to decrease | Recovered (p = 0.0119) | – | – | Suppl. Fig. 4b |
Grip strength | No change | No change | Muscle strength | Motor system | Suppl. Fig. 4c |
Wire hang test | No change | No change | Muscle strength | Motor system | Suppl. Fig. 4d |
Open field test | No change | No change | Anxiety, exploratory locomotion | Prefrontal cortex, cingulate cortex | Suppl. Fig. 4e–h |
Social interaction test | No change | No change | Anxiety in novel situation, sociality | Cognitive system (hippocampus, cingulate cortex) | Suppl. Fig. 4i–m |
Rotarod treadmill test | Hyperactive (p = 0.014) | No change | Muscle weakness, motor activity, coordination | Motor tract, cerebellum | Suppl. Fig. 4n |
Hot plate test | No change | No change | Pain and temperature sensation | Supraspinal sensory tract | Suppl. Fig. 4o |
Prepulse inhibition test | No change | No change | Sensorimotor gating, startle response, hearing acuity | Prefrontal cortex, hippocampus, striatum | Suppl. Fig. 4p, q |
Tail suspension test | No change | No change | Behavioral despair | Stria terminalis (basal forebrain) | Suppl. Fig. 4r |
Righting reflex | No change | No change | Postural maintenance, muscle strength | Vestibular system, muscle | Not shown |
Whisker twitch | No change | No change | Tactile sensation | Sensory system | Not shown |
Ear twitch | No change | No change | Tactile sensation | Sensory system | Not shown |
Reaching | No change | No change | Visual acuity | Visual system | Not shown |
Key jangling | No change | No change | Hearing acuity | Auditory system | Not shown |
