Fig. 1: CVD 1208S-122 vaccine reduced weight loss and diarrhea in both S. flexneri 2457T and ETEC H10407 infected mice. | npj Vaccines

Fig. 1: CVD 1208S-122 vaccine reduced weight loss and diarrhea in both S. flexneri 2457T and ETEC H10407 infected mice.

From: A bivalent vaccine confers immunogenicity and protection against Shigella flexneri and enterotoxigenic Escherichia coli infections in mice

Fig. 1: CVD 1208S-122 vaccine reduced weight loss and diarrhea in both S. flexneri 2457T and ETEC H10407 infected mice.

Mice receiving CVD 1208S-122 vaccine or the vector were infected with either Shigella flexneri or enterotoxigenic E. coli (ETEC) and observed daily for bodyweight changes and diarrhea presence. a CVD 1208S-122 vaccine effects on bodyweight changes induced by S. flexneri during the first week of infection. *P < 0.05 by two-way ANOVA + Tukey’s test, Shigella vs Shigella+Vaccine at days 4, 5, and 6 post-infection; &P < 0.05 by two-way ANOVA + Tukey’s test, Shigella vs Shigella + Vector at days 2 and 3 post-infection (two-way ANOVA P value < 0.001). b CVD 1208S-122 vaccine effects on bodyweight changes induced by ETEC during the first week of infection. *P < 0.05 by two-way ANOVA + Tukey’s test, ETEC vs ETEC + Vaccine at day 2 post-infection (two-way ANOVA P value < 0.001). Data are presented as mean with SEM. N = 16/group (N = 8 for Infected + Vector and N = 4 for Uninfected + Vector).

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