Table 3 Mucosal anti-gp41 and anti-gp140 IgG response magnitude is significantly increased vs. anti-gp120 IgG in cervical, rectal and oral secretions.

From: Meta-analysis of HIV-1 vaccine elicited mucosal antibodies in humans

 

Mediana

P-value

PFWERb

gp120 vs. gp140

 Cervical sponge

0.008 vs. 0.126

<0.0001

<0.0001***

 Rectal sponge

0.017 vs. 0.149

<0.0001

<0.0001***

 Saliva

0.016 vs. 0.069

<0.0001

<0.0001***

 Seminal plasma

0.009 vs. 0.024

<0.0001

<0.0001***

gp120 vs. gp41

 Cervical sponge

0.009 vs. 0.080

<0.0001

<0.0001***

 Rectal sponge

0.021 vs. 0.248

<0.0001

<0.0001***

 Saliva

0.016 vs. 0.068

0.0013

0.0065**

 Seminal plasma

0.012 vs. 0.007

0.1323

0.3969

gp140 vs. gp41

 Cervical sponge

0.126 vs. 0.074

0.8683

0.8683

 Rectal sponge

0.149 vs. 0.189

0.4994

0.8683

 Saliva

0.069 vs. 0.055

0.0126

0.0506

 Seminal plasma

0.024 vs. 0.007

<0.0001

<0.0001***

  1. Bold values are statistically significant.
  2. *PFWER ≤ 0.05; **PFWER ≤ 0.01; ***PFWER ≤ 0.001.
  3. aMedian among the participants who had a positive response to at least one antigen.
  4. bPFWER is the adjusted P-value for multiple comparisons to control the family-wide type I error rate.
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