Fig. 3: Cellular immune responses to vaccination with LAIV.

IFN-γ response in antigen-stimulated whole blood was determined by ELISA. Blood was stimulated with wild-type (a) H1N1 or (b) H3N2 viruses. Points show mean and standard error. The black line (All LAIV) shows the mean of all LAIV-vaccinated ferrets. The dotted horizontal line shows the limit of quantitation. *PBS/H3 group was significantly lower than the vaccinated groups on (a) day 8 and (b) day 11 (Mann–Whitney test, P < 0.0001, n = 6).