Fig. 5: Frequency and genome location of single nucleotide variants detected in SA14 and vaccine derivatives. | npj Vaccines

Fig. 5: Frequency and genome location of single nucleotide variants detected in SA14 and vaccine derivatives.

From: Japanese encephalitis virus live attenuated vaccine strains display altered immunogenicity, virulence and genetic diversity

Fig. 5

RNA was extracted and sequenced using Illumina methods. LoFreq software was used to detect SNVs in SA14 (A), SA14-14-2 (B), SA14-5-3 (C) and SA14-2-8 (D) samples. Dotted lines represent 50% of the population at which an SNV would become the consensus nucleotide and 1% of the population. An SNV frequency cutoff was applied at 0.05% frequency.

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