Fig. 6: Dose response of WT JEV and JEV vaccine strains to the antiviral ribavirin. | npj Vaccines

Fig. 6: Dose response of WT JEV and JEV vaccine strains to the antiviral ribavirin.

From: Japanese encephalitis virus live attenuated vaccine strains display altered immunogenicity, virulence and genetic diversity

Fig. 6

SA14, SA14-14-2, SA14-5-3 and SA14-2-8 were incubated with the GTP nucleoside analog, ribavirin. After 48 h, the supernatant was collected and titrated for viral load (FFU). Titers at each concentration were normalized to untreated, infected cells and fit using a dose-response linear regression. The experiment was undertaken in triplicate and points shown are an average of these experiments. A four-parameter, non-linear regression was used to fit sensitivity curves (SA14 R2 = 0.89, SA14-14-2 R2 = 0.89, SA14-5-3 R2 = 0.79, SA14-2-8 R2 = 0.964).

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