Fig. 5: Viral load and anamnestic responses in rhesus macaques following challenge with SARS-CoV-2 by the intranasal and intratracheal route.
From: Preclinical evaluation of a candidate naked plasmid DNA vaccine against SARS-CoV-2
a Peak and temporal SARS-CoV-2 viral loads, measured as SARS-CoV-2 E gene subgenomic mRNA, in BAL of pNTC-Spike vaccinated animals (N = 6) and untreated sham controls (N = 2). b Peak and temporal viral loads in nasal swabs of pNTC-Spike vaccinated animals and untreated sham controls. c End-point titers of binding IgG antibodies specific for the SARS-CoV-2 spike ectodomain on the day of virus challenge and days 2, 4, 7, and 10 following inoculation. Bar graphs indicate the median with interquartile range; Line graphs present each animal as a separate black line and the red line the median for each time point. Dotted lines indicate the assay limit of quantitation (1.69 log10 sgmRNA copies/mL).
