Fig. 3: Post-transfer binding and neutralizing antibody activity correlate with post-challenge body weight loss.

Correlation analyses were performed between post-transfer, pre-challenge binding and neutralizing antibody activity and the maximum body weight change following WA1/2020 SARS-CoV-2 challenge. In panels a–c, the median (a) WA1/2020 spike (S) or (b) WA1/2020 receptor binding domain (RBD) titer or (c) the median WA1/2020 pseudovirus neutralization titer was correlated with the median maximum body weight change. Data points displayed correspond to the median values for each group of hamsters corresponding to one study participant. To enable visualization of the full data set, panels d–g display similar analyses, with data points corresponding to all individual hamsters in the study shown. Median maximum body weight change was correlated with (d) WA1/2020 S binding, (e) WA1/2020 RBD binding, and (f) WA1/2020 pseudovirus NT50; data is displayed for all hamsters that received IgG from a vaccinee or placebo control. In panel (g) the buffer only and NHP IgG groups are also displayed to enable visualization of the experimental data set overlaid with negative and positive controls. Statistics displayed in all panels indicate the results of Spearman correlation analyses.