Fig. 1: Neurovirulence summary.
From: Evaluating stability of attenuated Sabin and two novel type 2 oral poliovirus vaccines in children
a Measured paralysis rate in modified mouse neurovirulence test. Datapoints are percent paralysis per EES. Paralysis rates for shed virus samples are indicated versus day of EES per vaccine. EES from participants with and without prior Sabin-2 exposure (via routine immunization) are shown by red or green circles. b Comparative analysis of neurovirulence. Datapoints are percent paralysis per EES following intraspinal administration of 104 CCID50 virus inoculum per mouse in the mTgmNVT. The p values indicated are based on estimated odds ratio of paralysis for shed virus of each nOPV2 candidate compared to Sabin-2. Displayed are the median (horizontal line), first and third quartiles (lower and upper box boundaries, respectively), with whiskers extending to the largest (smallest) value within 1.5 times the inter-quartile range of the upper (lower) box boundary.
