Fig. 3: nOPV2-c1.
From: Evaluating stability of attenuated Sabin and two novel type 2 oral poliovirus vaccines in children
Frequency of polymorphisms in EES at known attenuation sites and mTgmNVT results. EES day shown with mTgmNVT result (red color gradient) and polymorphism frequency (blue color gradient) averaged across two stool replicates (SS) and culture-amplified virus (I), if present. Amino acid associated with SNP indicated, if applicable. S = Stool replicate; I = Culture-amplified virus isolate (SSI = Two stool replicates and culture-amplified virus isolate; SI = Single stool replicate and isolate). White cells = polymorphism not detected. Gray cells = mTgmNVT result not available or no NGS data from stool (S)/ culture-amplified virus (I). *Day 5 = Insufficient titer to test EES in mTgmNVT. The NGS pipeline reports SNPs. Coding impact assumes changes are not in common genomes when multiple polymorphisms are observed in VP1-143. All SNPS reported have Q scores ≥ 30.
