Fig. 4: Co-administering Gcc-foldon and Pre-F-NP did not result in antigenic interference in MIMIC®. | npj Vaccines

Fig. 4: Co-administering Gcc-foldon and Pre-F-NP did not result in antigenic interference in MIMIC®.

From: Immunogenicity and protective efficacy of RSV G central conserved domain vaccine with a prefusion nanoparticle

Fig. 4: Co-administering Gcc-foldon and Pre-F-NP did not result in antigenic interference in MIMIC®.

a Gcc-specific IgG titers were measured after stimulating cells with Gcc-Foldon or Gcc-Foldon co-administered with pre-F-NP at a 1:1 ratio. b Pre-F-specific IgG titers were measured after stimulating cells with pre-F-NP alone or pre-F-NP co-administered with Gcc-Foldon at a 1:1 ratio. Ab binding titers were determined using the Antibody Forensics technique with Luminex beads coated with peptide corresponding to the RSV Gcc of strain A2 or DS-Cav1 (pre-F). In each panel, the immunogen used for stimulation is indicated below the graph. Each dot represents a response from an individual donor, the lines indicate the geometric means, and error bars represent 95% confidence intervals. For comparison, the unstimulated control is labeled as none. N = 20. All statistical values were performed using Student’s t-test.

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