Fig. 1: Construction of the immune-enhancing FMDV vaccine strains, O PA2-C3d and A22-C3d. | npj Vaccines

Fig. 1: Construction of the immune-enhancing FMDV vaccine strains, O PA2-C3d and A22-C3d.

From: The C3d-fused foot-and-mouth disease vaccine platform overcomes maternally-derived antibody interference by inducing a potent adaptive immunity

Fig. 1

(a, b) O PA2-C3d (a); A22-C3d (b). The B cell epitope, C3d (with 13 amino acid residues in the VP1 region) is used to prepare the virus. The O PA2 (O PA2-R) or A22 (A22-R) P1 strains—where the P1 region of O1 Manisa is substituted with O PA2 P1 or A22 P1—are used as the backbone to prepare the immune-enhancing FMD vaccine strains that can overcome interference by maternally-derived antibodies.

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