Fig. 5: Adjuvants boosted IgG antibodies against head H5 HA proteins post second dose.
From: The antibody landscapes following AS03 and MF59 adjuvanted H5N1 vaccination
IgG antibody landscapes for HA1 subunit antigens based on mean log2 fold change relative to pre-vaccination adjusted for seasonal influenza vaccination (Experiment 1). In red: Group 1 HA1 antigens, in blue: Group 2 HA1 antigens, in purple: influenza B HA1. The y and x axes project antigen protein sequence divergence as measured in the number of amino acid differences between antigen protein using multidimensional scaling. For each antigen, first the mean log2 fold change in antibody fluorescent intensity relative to pre-vaccination adjusted for prior seasonal influenza vaccination was determined (LSMEAN). For subtypes with multiple antigens, the mean LSMEAN and MDS dimensions were used to present the results in the 3D space.
