Fig. 7: All three vaccines elicited increased IgG antibodies against full-length H5 proteins after the first dose without further boosting after the second dose.
From: The antibody landscapes following AS03 and MF59 adjuvanted H5N1 vaccination
IgG antibody landscapes for HA0 antigens based on mean log2 fold change relative to pre-vaccination adjusted for seasonal influenza vaccination (Experiment 2). In red: Group 1 HA0 antigens, in blue: Group 2 HA0 antigens, in purple: influenza B HA0. The y and x axes project antigen protein sequence divergence as measured in the number of amino acid differences between antigen proteins using multidimensional scaling. For each antigen, first the mean log2 fold change in antibody fluorescent intensity relative to pre-vaccination adjusted for prior seasonal influenza vaccination was determined (LSMEAN). For subtypes with multiple antigens, the mean LSMEAN and MDS dimensions were used to present the results in the 3D space.
