Fig. 5: Co-administration of heat-iMVA promotes trafficking of antigen-carrying migratory DC into skin draining LN and activation of resident dendritic cells. | npj Vaccines

Fig. 5: Co-administration of heat-iMVA promotes trafficking of antigen-carrying migratory DC into skin draining LN and activation of resident dendritic cells.

From: Heat-inactivated modified vaccinia virus Ankara boosts Th1 cellular and humoral immunity as a vaccine adjuvant

Fig. 5: Co-administration of heat-iMVA promotes trafficking of antigen-carrying migratory DC into skin draining LN and activation of resident dendritic cells.The alternative text for this image may have been generated using AI.

C57/B6J mice were intradermally vaccinated with OVA647 (5 μg) in the presence or absence of heat-iMVA (107 pfu). a, b After 24 h, OVA647 intensities in different dendritic cells populations from dLNs were measured. c Representative dot plots of OVA647 expression in CD11b+ dendritic cells. d, e After 24 h, CD86 expressions in different dendritic cells populations from dLNs were measured. f Representative dot plots of CD86 expression in CD8+ dendritic cells. Data are represented as mean ± SEM (n = 3-5; *P < 0.05, and **P < 0.01; Two-tailed Mann-Whitney U test). Data are representative of three independent experiments.

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