Table 1 Half-effective dosage (ED50) of double-type and triple-type chimeras in mice.

From: Characterization of an Escherichia coli-derived triple-type chimeric vaccine against human papillomavirus types 39, 68 and 70

Antigen category

HPV VLP

ED50 (μg)

  

anti-HPV39

anti-HPV68

anti-HPV70

Wild-type control

HPV39

0.022

>0.900

–

HPV68

>0.900

0.023

–

HPV39&68

0.021

0.023

–

Double-type chimera

H39–68FG

0.091

0.405

–

H68-39BC

0.395

0.021

–

H68-39HI

>0.900

0.028

–

Wild-type control

HPV39

0.019

>0.900

>0.900

HPV68

>0.900

0.021

0.900

HPV70

>0.900

>0.900

0.019

HPV39&68&70

0.021

0.021

0.021

Triple-type chimera

H39–68FG-70DE

0.021

0.030

0.040

H39–68FG-70EF

0.900

0.024

0.611

H39–68FG-70HI

0.022

0.148

0.047

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