Table 1 Baseline characteristics of two-dose vaccine recipients without prior infection and one-dose recipients with prior infection.
From: Comparing hybrid and regular COVID-19 vaccine-induced immunity against the Omicron epidemic
BNT162b2 | CoronaVac | |||||
|---|---|---|---|---|---|---|
With prior SARS‑CoV‑2 infection | Without prior SARS‑CoV‑2 infection | With prior SARS‑CoV‑2 infection | Without prior SARS‑CoV‑2 infection | |||
n | 5389 | 1,556,405 | SMDb | 2026 | 1,105,711 | SMDb |
Sex = Male (%) | 2645 (49.1) | 698,876 (44.9) | 0.042 | 921 (45.5) | 504,875 (45.7) | 0.002 |
Age [mean (SD)] | 44.28 (16.40) | 45.85 (17.04) | 0.094 | 54.93 (14.56) | 56.86 (14.40) | 0.133 |
Index date to outbreaka [in days, mean (SD)] | 176.42 (58.12) | 153.71 (56.97) | 0.395 | 174.38 (71.64) | 161.28 (67.55) | 0.188 |
Chronic conditions (%) | ||||||
Alcohol misuse | 5 (0.1) | 2842 (0.2) | 0.001 | 5 (0.2) | 2893 (0.3) | 0.001 |
Asthma | 42 (0.8) | 14,287 (0.9) | 0.001 | 21 (1.0) | 10,028 (0.9) | 0.001 |
Atrial fibrillation | 23 (0.4) | 5931 (0.4) | <0.001 | 17 (0.8) | 8712 (0.8) | <0.001 |
Cancer lymphoma | 4 (0.1) | 993 (0.1) | <0.001 | 1 (0.0) | 713 (0.1) | 0.001 |
Cancer metastatic | 2 (0.0) | 2238 (0.1) | 0.001 | 4 (0.2) | 2167 (0.2) | <0.001 |
Cancer non-metastatic | 16 (0.3) | 9512 (0.6) | 0.003 | 14 (0.7) | 9206 (0.8) | 0.001 |
Chronic heart failure | 5 (0.1) | 2787 (0.2) | 0.001 | 11 (0.5) | 4136 (0.4) | 0.001 |
Chronic kidney disease | 43 (0.8) | 16,300 (1.0) | 0.002 | 44 (2.2) | 19,748 (1.8) | 0.004 |
Chronic pain | 90 (1.7) | 27,762 (1.8) | 0.001 | 35 (1.7) | 27,425 (2.5) | 0.008 |
Chronic pulmonary disease | 18 (0.3) | 4716 (0.3) | <0.001 | 13 (0.6) | 7302 (0.7) | 0.001 |
Chronic viral hepatitis B | 38 (0.7) | 14,024 (0.9) | 0.002 | 28 (1.4) | 17,010 (1.5) | 0.001 |
Cirrhosis | 2 (0.0) | 1305 (0.1) | 0.001 | 0 (0.0) | 1410 (0.1) | 0.001 |
Dementia | 1 (0.0) | 730 (0.0) | <0.001 | 2 (0.1) | 1776 (0.2) | 0.001 |
Depression | 69 (1.3) | 26,534 (1.7) | 0.004 | 32 (1.6) | 19,403 (1.8) | 0.002 |
Diabetes | 390 (7.2) | 108,130 (6.9) | 0.003 | 235 (11.6) | 142,314 (12.9) | 0.013 |
Epilepsy | 8 (0.1) | 2385 (0.2) | 0.001 | 6 (0.3) | 1846 (0.2) | 0.001 |
Hypertension | 678 (12.6) | 213,350 (13.7) | 0.011 | 401 (19.8) | 274,336 (24.8) | 0.050 |
Hypothyroidism | 51 (0.9) | 18,447 (1.2) | 0.003 | 25 (1.2) | 17,690 (1.6) | 0.004 |
Inflammatory bowel disease | 4 (0.1) | 1137 (0.1) | <0.001 | 1 (0.0) | 601 (0.1) | 0.001 |
Irritable bowel syndrome | 2 (0.0) | 1636 (0.1) | 0.001 | 4 (0.2) | 1102 (0.1) | 0.001 |
Multiple sclerosis | 3 (0.1) | 503 (0.0) | 0.001 | 1 (0.0) | 192 (0.0) | <0.001 |
Myocardial infarction | 11 (0.2) | 2328 (0.1) | 0.001 | 10 (0.5) | 3045 (0.3) | 0.002 |
Parkinson’s disease | 1 (0.0) | 954 (0.1) | 0.001 | 1 (0.0) | 1235 (0.1) | 0.001 |
Peptic ulcer disease | 10 (0.2) | 3673 (0.2) | <0.001 | 6 (0.3) | 4914 (0.4) | 0.001 |
Peripheral vascular disease | 1 (0.0) | 555 (0.0) | <0.001 | 1 (0.0) | 789 (0.1) | 0.001 |
Psoriasis | 4 (0.1) | 1869 (0.1) | <0.001 | 4 (0.2) | 1500 (0.1) | 0.001 |
Rheumatoid arthritis | 8 (0.1) | 3839 (0.2) | 0.001 | 4 (0.2) | 3255 (0.3) | 0.001 |
Schizophrenia | 10 (0.2) | 3776 (0.2) | <0.001 | 7 (0.3) | 4030 (0.4) | 0.001 |
Severe constipation | 81 (1.5) | 29,601 (1.9) | 0.004 | 45 (2.2) | 33,280 (3.0) | 0.008 |
Stroke or transient ischemic attack | 22 (0.4) | 9076 (0.6) | 0.002 | 19 (0.9) | 13,423 (1.2) | 0.003 |
Medications (%) | ||||||
Renin–angiotensin system agents | 361 (6.7) | 124,195 (8.0) | 0.013 | 227 (11.2) | 153,502 (13.9) | 0.027 |
Beta blockers | 207 (3.8) | 74,256 (4.8) | 0.010 | 118 (5.8) | 90,726 (8.2) | 0.024 |
Calcium channel blockers | 537 (10.0) | 181,243 (11.6) | 0.016 | 320 (15.8) | 234,242 (21.2) | 0.054 |
Diuretics | 37 (0.7) | 18,489 (1.2) | 0.005 | 35 (1.7) | 24,038 (2.2) | 0.005 |
Nitrates | 47 (0.9) | 13,950 (0.9) | <0.001 | 35 (1.7) | 18,675 (1.7) | <0.001 |
Lipid-lowering agents | 502 (9.3) | 181,597 (11.7) | 0.024 | 293 (14.5) | 224,652 (20.3) | 0.058 |
Insulins | 48 (0.9) | 11,974 (0.8) | 0.001 | 40 (2.0) | 13,628 (1.2) | 0.008 |
Antidiabetic drugs | 319 (5.9) | 94,392 (6.1) | 0.002 | 194 (9.6) | 121,405 (11.0) | 0.014 |
Antiarrhythmic drugs | 0 (0.0) | 1053 (0.1) | 0.001 | 1 (0.0) | 1073 (0.1) | 0.001 |
Oral anticoagulants | 19 (0.4) | 5319 (0.3) | 0.001 | 10 (0.5) | 7112 (0.6) | 0.001 |
Antiplatelets | 163 (3.0) | 55,704 (3.6) | 0.006 | 116 (5.7) | 74,232 (6.7) | 0.010 |
Steroid | 40 (0.7) | 8535 (0.5) | 0.002 | 19 (0.9) | 6730 (0.6) | 0.003 |
Antidepressant | 113 (2.1) | 49,718 (3.2) | 0.011 | 57 (2.8) | 43,279 (3.9) | 0.011 |
Antiviral drugs | 82 (1.5) | 16,212 (1.0) | 0.005 | 59 (2.9) | 15,792 (1.4) | 0.015 |
Antibacterial drugs | 154 (2.9) | 46,977 (3.0) | 0.001 | 66 (3.3) | 35,050 (3.2) | 0.001 |
Immunosuppressants | 21 (0.4) | 5161 (0.3) | 0.001 | 18 (0.9) | 3365 (0.3) | 0.006 |
