Table 3 Incidence rate ratios of study outcomes between vaccine recipients not previously infected and non-vaccine recipients with a previous infection.

From: Comparing hybrid and regular COVID-19 vaccine-induced immunity against the Omicron epidemic

 

Number of individuals

Event

Total duration of follow-up (person-days)

Incidence ratea

Incidence rate ratio (95% confidence interval)b, p-value

Crude

Adjustedc

SARS-CoV-2 infection

BNT162b2

Vaccinated with 2 doses of BNT162b2

1,556,405

126,907

341,094,574

37.206

Ref

Ref

With history of infection and unvaccinated

10,207

64

3,299,894

1.939

0.052 (0.041, 0.067), <0.001

0.622 (0.486, 0.795), <0.001

CoronaVac

Vaccinated with 2 doses of CoronaVac

1,105,711

92,900

231,341,350

40.157

Ref

Ref

With history of infection and unvaccinated

10,207

64

3,299,894

1.939

0.048 (0.038, 0.062), <0.001

0.746 (0.584, 0.953), 0.019

COVID-19 hospitalization

BNT162b2

Vaccinated with 2 doses of BNT162b2

1,556,405

3,343

344,734,316

0.970

Ref

Ref

With history of infection and unvaccinated

10,207

6

3,301,470

0.182

0.187 (0.084, 0.417), <0.001

0.793 (0.350, 1.799), 0.579

CoronaVac

Vaccinated with 2 doses of CoronaVac

1,105,711

3,026

233,887,234

1.294

Ref

Ref

With history of infection and unvaccinated

10,207

6

3,301,470

0.182

0.140 (0.063, 0.313), <0.001

2.197 (0.979, 4.932), 0.056

COVID-19 mortality

BNT162b2

Vaccinated with 2 doses of BNT162b2

1,556,405

94

344,887,368

0.027

Ref

Ref

With history of infection and unvaccinated

10,207

1

3,301,618

0.030

1.111 (0.155, 7.971), 0.916

1.413 (0.151, 13.186), 0.762

CoronaVac

Vaccinated with 2 doses of CoronaVac

1,105,711

350

233,980,242

0.150

Ref

Ref

With history of infection and unvaccinated

10,207

1

3,301,618

0.030

0.202 (0.029, 1.431), 0.109

2.397 (0.317, 18.104), 0.397

  1. aIncidence rate per 100,000 person-day.
  2. bIncidence rate ratios for outcomes with zero events were not estimated.
  3. cAdjusted for age, sex, number of days from the index date to the local Omicron outbreak (January 1, 2022), clinical history of chronic conditions before the index date (Supplementary Table 5), and medications prescribed within 90 days before the index date (Supplementary Table 6).