Table 1 Advances studies on microfluidic cell squeeze technology.
From: Microfluidic cell squeeze-based vaccine comes into clinical investigation
Drug name | Cells | Target | NCT | Study stage | Cancer type | Treatment |
|---|---|---|---|---|---|---|
SQZ-PBMC-HPV-101 | Peripheral blood mononuclear cells | HPV16 viral oncoprotein E6 and E7 | NCT04084951 | I/II | HPV16 + solid tumors | Monotherapy or combined immune checkpoint inhibitors |
SQZ-AAC-HPV | Red blood cells | immunogenic epitopes of HPV16 | NCT04892043 | I | HPV16 + solid tumors | Monotherapy or combined immune checkpoint inhibitors |
SQZ-eAPC-HPV | Peripheral blood mononuclear cells | incorporating 5 mRNAs | NCT05357898 | I/II | HPV16 + solid tumors | Monotherapy or combined immune checkpoint inhibitors |
