Fig. 1: CCHFV genome and rhabdoviral-based CCHFV vaccine vector maps.
From: GP38 as a vaccine target for Crimean-Congo hemorrhagic fever virus
Schematics of the CCHFV genome and virion (a), and RABV- and VSV-based CCHFV vaccines and their vector controls (b). All foreign genes were inserted into the BNSP333 vector between N and P and between M and L for the VSV vector. The GP85 chimeric gene is expanded to show the various sections of both GP85 and the RABV-G that were included in the gene. Attenuating R333E mutation is marked in RABV-G. RdRp RNA-dependent RNA polymerase, MLD Mucin-like domain, NSM non-structural M protein, NP nucleoprotein, N nucleoprotein, P Phosphoprotein, M matrix protein, G glycoprotein, L polymerase, ED51 51 amino acids of the ectodomain, TM transmembrane domain, CD cytoplasmic domain. Created with Biorender.com.
