Table 3 Summary of maternal delivery and pup data in PPND study.

From: Developmental and reproductive toxicity of a recombinant protein subunit COVID-19 vaccine (ZF2001) in rats

Indicators

Blank control

ZF2001 25 μg/dose

Total females

28

28

Female mating indexa

19/28 (67.9%)

20/28 (71.4%)

Pregnancy rateb

16/19 (84.2%)

16/20 (80.0%)

Parturition ratec

16/16 (100%)

16/16 (100%)

Females with unsuccessful deliveryd

0

0

Gestation length (days)

21.8 ± 0.4

21.6 ± 0.5

Pups per litter at birth

12.56 ± 3.27

12.44 ± 3.43

Live pups per litter at birth

12.50 ± 3.18

12.31 ± 3.34

Survival rate at birthe

99.5%

99.0%

Survival rate on PND 4f

97.0%

98.5%

Survival rate in lactation (on PND21)g

100%

100%

External malformation rate of pups born

0%

0%

Sex ratio of pups(♂/♀)

77/123

87/110

Pup body weight on PND 0 (g)

6.59 ± 0.58

6.89 ± 0.86

Pup body weight on PND 4 (g)

10.73 ± 1.15

10.96 ± 1.24

Pup body weight on PND 7 (g)

17.44 ± 0.97

17.83 ± 1.50

Pup body weight on PND 10 (g)

25.10 ± 1.62

25.60 ± 2.13

Pup body weight on PND 14 (g)

35.71 ± 2.30

36.46 ± 2.93

Pup body weight on PND 17 (g)

43.05 ± 2.82

44.36 ± 3.47

Pup body weight on PND 21 (g)

57.97 ± 4.81

59.66 ± 5.20

  1. Data are expressed as the mean per litter ± standard deviation, number or the percentage.
  2. aFemale mating index = Females mated/Total females × 100%.
  3. bPregnancy rate = Pregnant females/Females mated × 100%.
  4. cParturition rate = Females that have completed parturition/Pregnant females × 100%.
  5. dUnsuccessful delivery includes miscarriage, dystocia, premature, late or incomplete delivery.
  6. eSurvival rate at birth = Number of pups born alive/Number of pups born × 100%.
  7. fSurvival rate on PND 4 = Number of live pups on PND 4/Number of pups born alive × 100%.
  8. gSurvival rate in lactation = Number of live pups on PND 21/Number of live pups after post-cull on PND 4 × 100%.
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