Table 4 Postnatal day when developmental signs were attained in F1 pups in PPND study.

From: Developmental and reproductive toxicity of a recombinant protein subunit COVID-19 vaccine (ZF2001) in rats

Indicators

Blank control

ZF2001 25 μg/dose

Total litters

16

16

Physical development

 Auricle separation

3.1 ± 0.7

3.4 ± 0.5

 Incisor eruption

11.1 ± 0.7

11.0 ± 0.6

 Appearance of fur

11.9 ± 0.5

12.0 ± 0.4

 Eyes opening

15.0 ± 0.4

15.2 ± 0.5

 Pinna unfolding

16.9 ± 0.6

16.8 ± 0.8

Reflex development

 Plane Correction

4.4 ± 0.9

4.2 ± 1.1

 Negative geotaxis

8.6 ± 0.8

8.9 ± 1.2

 Auditory Startle

13.7 ± 1.4

13.3 ± 0.9

 Aerial righting

15.8 ± 0.9

15.8 ± 0.6

 Pupillary reflex

15.0 ± 0.4

15.2 ± 0.5

Sexual development

 Vaginal opening

34.0 ± 1.8

33.9 ± 2.3

 Preputial separation

40.6 ± 1.0

40.4 ± 1.0

  1. Data presented as mean age (day at which 100% pups attained landmark) per litter ± standard deviation.
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