Table 6 Modified Irwin’s behavioural assessment of F1 offspring rats in PPND study.

From: Developmental and reproductive toxicity of a recombinant protein subunit COVID-19 vaccine (ZF2001) in rats

Indicators

Classification

Blank control

ZF2001 25 μg/dose

Total fetuses

 

32

32

Spontaneous activity

 Body position

Normal:

32/32

32/32

 Bizarre behaviour

Not found:

32/32

32/32

 Restlessness

Not found:

32/32

32/32

Autonomic

 Piloerection

Not found:

32/32

32/32

 Abnormal coat

Not found:

32/32

32/32

 Palpebral ptosis/closure

Not found:

32/32

32/32

 Respiratory rate

Normal:

32/32

32/32

 Lacrimation

Not found:

32/32

32/32

 Salivation

Not found:

32/32

32/32

 Exophthalmos

Not found:

32/32

32/32

 Skin colour

Not found:

32/32

32/32

Motor-affective response

 Vocalisation

Not found:

27/32

28/32

Stress reaction:

5/32

4/32

 Urination

Not found:

31/32

30/32

Stress reaction:

1/32

2/32

 Defecation

Not found:

32/32

32/32

 Provoked biting

Not found:

32/32

32/32

 Transfer arousal

No reaction:

5/32

12/32

Minor reaction:

12/32

9/32

Normal:

15/32

11/32

 Spatial locomotion

Normal:

32/32

32/32

 Touch escape

No reaction:

29/32

30/32

Minor reaction:

3/32

2/32

 Positional passivity

Not found:

32/32

32/32

CNS excitation

 Tremor

Not found:

32/32

32/32

 Twitch

Not found:

32/32

32/32

 Convulsion

Not found:

32/32

32/32

Muscle tone

 Body tone

Normal:

32/32

32/32

 Grip strength

Normal:

32/32

32/32

Sensory-motor response

 Pinna reflex

Normal:

32/32

32/32

 Corneal reflex

Normal:

32/32

32/32

 Visual placing reflex

Normal:

32/32

32/32

 Startle reflex

Normal:

32/32

32/32

 Tail-pinch reflex

Normal:

32/32

32/32

Posture

 Tail elevation

Not found:

32/32

32/32

Equilibrium and gait

 Ataxic gait

Not found:

32/32

32/32

 Hypotonic gait

Not found:

32/32

32/32

 Total gait incapacity

Not found:

32/32

32/32

 Surface righting reflex

Normal:

32/32

32/32

 Spatial righting reflex

Normal:

32/32

32/32

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