Table 7 Summary of reproductive performance of F1 offspring rats in PPND study.

From: Developmental and reproductive toxicity of a recombinant protein subunit COVID-19 vaccine (ZF2001) in rats

Indicators

Blank control

ZF2001 25 μg/dose

Total pairs cohabited

16

16

Mated females

16

15

Pregnant females

15

14

Time to mating (days)

3.3 ± 1.7

3.2 ± 0.9

Mating index (%)

100

93.8

Pregnancy (%)

93.8

93.3

Fertility index (%)

93.8

87.5

Corpus lutea

21.2 ± 6.8

23.6 ± 5.2

Implantation

16.2 ± 1.9

16.3 ± 2.5

Live fetuses

14.8 ± 2.1

14.9 ± 2.2

Live fetuses (%)

91.4 ± 9.8

91.5 ± 7.8

Dead fetuses

0.0 ± 0.0

0.0 ± 0.0

Dead fetuses (%)

0.0 ± 0.0

0.0 ± 0.0

Resorptions

1.4 ± 1.7

1.4 ± 1.4

Resorptions (%)

8.6 ± 9.8

8.5 ± 7.8

Preimplantation loss (%)

19.9 ± 15.1

28.4 ± 15.9

Postimplantation loss (%)

8.6 ± 9.8

8.5 ± 7.8

  1. Data in each group presented as mean per litter ± standard deviation.
  2. Mating index = Females mated/females cohabited × 100%.
  3. Pregnancy (%) = Pregnant females/Females mated × 100%.
  4. Fertility index = Pregnant females/females cohabited × 100%.
  5. Live fetuses (%) = Live fetuses/Implantation sites × 100%.
  6. Dead fetuses (%) = Dead fetuses/Implantation sites × 100%.
  7. Resorptions (%) = Resorptions/Implantation sites × 100%.
  8. Preimplantation loss (%) = (Corpus lutea-Implantation sites)/Corpus lutea × 100%.
  9. Postimplantation loss (%) = (Implantation sites-Live fetuses)//Corpus lutea × 100%.