Fig. 2: Attenuation of YF-EBO. | npj Vaccines

Fig. 2: Attenuation of YF-EBO.

From: YF17D-vectored Ebola vaccine candidate protects mice against lethal surrogate Ebola and yellow fever virus challenge

Fig. 2

a Weight evolution and b survival curve of Ifnar-/- mice after intraperitoneal inoculation with 250 PFU of YF-EBO (n = 6, green circles), YF17D (n = 6, yellow circles), or sham (n = 6, white circles) as a control. c Weight evolution and d survival curve of AG129 mice after intraperitoneal inoculation with 250 PFU of YF-EBO (n = 8), YF17D (n = 6) or sham (n = 6) as a control. e Weight evolution and f survival curve of 5-day-old suckling BALB/c mice after intracranial inoculation with 25 PFU of YF-EBO (n = 12), 10 PFU of YF17D (n = 10) or sham (n = 6) as a control. The number of surviving mice at study endpoint are indicated within parentheses in the legends and a log-rank test was applied to compare YF-EBO- with YF17D-vaccinated mice, significant p values < 0.05 are indicated (b, d, f). Error bars indicate SEM (a, c).

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