Fig. 5: Antibody (cross)-reactivity of distinct YF17D-vectored ebolavirus vaccine candidates.
a Schematic of YF17D-vectored ebolavirus vaccine constructs and representative images of their plaque phenotypes on BHK-21J cells, fixed 6 days post-infection. b Heatmap representing the different ebolavirus GPs (EBOV GP, SUDV GP, TAFV GP, BDBV GP and RESTV GP) log10-transformed mean binding antibody titers present in serum pools of Ifnar-/- mice that were hyperimmunized with either YF-EBO, YF-SUD, YF-TAF, YF-BDB or YF17D determined by IIFA (n = 2). Phylogenetic tree based on the amino acid sequences of the different ebolavirus GPs was generated using the Neighbor-Joining method with 1000 bootstrap replications in MEGA1159. Small numbers at the nodes and the scale bar indicate bootstrap values and the number of amino acid substitutions per site, respectively.
