Fig. 4: Interconnectivity between prioritized high confidence transcription factors. | npj Vaccines

Fig. 4: Interconnectivity between prioritized high confidence transcription factors.

From: Identifying a causal link between prolactin signaling pathways and COVID-19 vaccine-induced menstrual changes

Fig. 4

a Direct interactions network of five higher confidence causal transcription factors. b Direct interactions network of five higher confidence causal transcription factors in addition to prolactin (PRL). c Direct interactions network of 33 causal upstream regulators that are known biomarkers for menstrual disturbances. d Direct interactions network of 33 causal upstream regulators that are known biomarkers for menstrual disturbances, in addition to prioritized 5 topological genes and PRL. Thick edges correspond to confidence score \(\ge\) 0.70 (i.e., high confidence score), while the thin edge corresponds to a confidence level \(\le\) 0.50 (i.e., low confidence score). Nodes are color-coded using a split pie chart coloring scheme indicating pathway/gene set contribution to each node from the top 5 most enriched pathways/gene lists. FDR values represent he significance of the predicted pathway. Generated based on STRING data on 27 September 2022.

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